Structure of PDB 5f6k Chain C Binding Site BS02
Receptor Information
>5f6k Chain C (length=150) Species:
9606
(Homo sapiens) [
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PLGSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGT
IIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAP
NCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFIPCHCGAVNCRKWMN
Ligand information
>5f6k Chain M (length=6) Species:
9606
(Homo sapiens) [
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RTKQTA
Receptor-Ligand Complex Structure
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PDB
5f6k
Structural basis for activity regulation of MLL family methyltransferases.
Resolution
2.411 Å
Binding residue
(original residue number in PDB)
N4811 E4814 V4824 M4826 F4827 Y4886 K4887 F4888
Binding residue
(residue number reindexed from 1)
N58 E61 V71 M73 F74 Y133 K134 F135
Enzymatic activity
Catalytic site (original residue number in PDB)
Y4800 I4876
Catalytic site (residue number reindexed from 1)
Y47 I123
Enzyme Commision number
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:5f6k
,
PDBe:5f6k
,
PDBj:5f6k
PDBsum
5f6k
PubMed
26886794
UniProt
Q8NEZ4
|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)
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