Structure of PDB 5eg6 Chain C Binding Site BS02

Receptor Information

>5eg6 Chain C (length=413) Species: 10090 (Mus musculus)

PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLM
GSGWKKKKEQMERDGCSEQESQPCAFIGIGNSEMQQLNLEGKNYCTAKTL
YISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKQSLKNADLC
IASGTKVALFNRLTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESEGE
EFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQL
HKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIIST
DKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGDVAMLELTGQNFTPNLRV
WFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGV
IYSTSLTFTYTPE

Ligand information

>5eg6 Chain R (length=16) Species: 32630 (synthetic construct)

DAAKLRALLWTPPPTP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5eg6 CSL-RITA complex bound to DNA
• Resolution: 2.094 Å
• Binding residue (original residue number in PDB): N235 F236 H249 E259 E260 F261 T262 V263 D265 G282 M283 A284 L285 P286 I332 Q333 F334
• Binding residue (residue number reindexed from 1): N176 F177 H190 E200 E201 F202 T203 V204 D206 G223 M224 A225 L226 P227 I273 Q274 F275

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:5eg6, PDBe:5eg6, PDBj:5eg6
• PDBsum: 5eg6
• UniProt: P31266|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)