Structure of PDB 5cdo Chain C Binding Site BS02

Receptor Information
>5cdo Chain C (length=480) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTP
DKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNF
GSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVL
PARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELM
EDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIV
VTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRK
DANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQK
TVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMES
LQQRFKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILA
DEEVLLQLVRDELTEIRDRFGDDRRTEIQL
Ligand information
Receptor-Ligand Complex Structure
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PDB5cdo Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		R33 K43 H46 H79 H81 R92 S173 I175 R272
Binding residue
(residue number reindexed from 1)		R23 K33 H36 H69 H71 R82 S163 I165 R262
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5cdo, PDBe:5cdo, PDBj:5cdo
PDBsum5cdo
PubMed26640131
UniProtQ99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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