Structure of PDB 5bk4 Chain C Binding Site BS02

Receptor Information
>5bk4 Chain C (length=646) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRIIWGTNVSIQECTTNFRNFLMSFKYKFRKILDERDEELYYIKQLNEMR
ELGTSNLNLDARNLLAYKQTEDLYHQLLNYPQEVISIMDQTIKDCMVSLI
VDNNLDYDLDEIETKFYKVRPYNVGSCKGMRELNPNDIDKLINLKGLVLR
STPVIPDMKVAFFKCNVCDHTMAVEIDRGVIQEPARCERIDCNEPNSMSL
IHNRCSFADKQVIKLQETPDFVPDGQTPHSISLCVYDELVDSCRAGDRIE
VTGTFRSIPIRANSRQRVLKSLYKTYVDVVHVKVSDKRLDVDTSTIEQEL
MQNKVDHNEVEEVRQITDQDLAKIREVAAREDLYSLLARSIAPSIYELED
VKKGILLQLFGGTNKTFTKGGRYRGDINILLCGDPSTSKSQILQYVHKIT
PRGVYTSGKGSSAVGLTAYITRDVDTKQLVLESGALVLSDGGVCCIDEFD
KMSDSTRSVLHEVMEQQTISIAKAGIITTLNARSSILASANPIGSRYNPN
LPVTENIDLPPPLLSRFDLVYLVLDKVDEKNDRELAKHLTNLYLEDKPEH
ISQDDVLPVEFLTMYISYAKEHIHPIITEAAKTELVRAYVGMRKMGDRIT
ATTRQLESMIRLAEAHAKMKLKNVVELEDVQEAVRLIRSAIKDYAT
Ligand information
>5bk4 Chain O (length=60) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
actgactgactgactgactgactgactgactgactgactgactgactgac
tgactgactg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5bk4 Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R449 Q450
Binding residue
(residue number reindexed from 1)		R265 Q266
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006279 premeiotic DNA replication
GO:0032508 DNA duplex unwinding
GO:0033260 nuclear DNA replication
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005737 cytoplasm
GO:0031261 DNA replication preinitiation complex
GO:0031298 replication fork protection complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
GO:0071162 CMG complex
GO:0097373 MCM core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5bk4, PDBe:5bk4, PDBj:5bk4
PDBsum5bk4
PubMed29078375
UniProtP30665|MCM4_YEAST DNA replication licensing factor MCM4 (Gene Name=MCM4)

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