Structure of PDB 5b4w Chain C Binding Site BS02

Receptor Information

>5b4w Chain C (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLD
SRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLG
QLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQAGEPLLFVGRGYTSRGI
PPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFL
FLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAV
ATSREVAHGEVLFAAFSSAAPRPPSAAAASALCAFPLDEVDRLANRTRDA
CYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASR
VPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDG
HPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVAS

Ligand information

>5b4w Chain J (length=16) Species: 32644 (unidentified) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

WRPRVARWTGQIIYCS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
Resolution	2.6 Å
Binding residue (original residue number in PDB)	R245 G270 R272 T351 E352 P391
Binding residue (residue number reindexed from 1)	R214 G239 R241 T312 E313 P352

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0017154	semaphorin receptor activity

	Biological Process
GO:0071526	semaphorin-plexin signaling pathway

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Molecular Function

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Biological Process

External links

PDB	RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum	5b4w
PubMed	27984026
UniProt	O43157\|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

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