Structure of PDB 4zrk Chain C Binding Site BS02

Receptor Information
>4zrk Chain C (length=295) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI
KDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLF
FLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL
LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG
VNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSD
KEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA
Ligand information
>4zrk Chain G (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PKFGTHHKALQEIRNSLLPFAN
Receptor-Ligand Complex Structure
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PDB4zrk Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Resolution2.316 Å
Binding residue
(original residue number in PDB)		E136 A137 L140 Y144 L176 Y177 Q178 M179 W191 E194 E206
Binding residue
(residue number reindexed from 1)		E118 A119 L122 Y126 L158 Y159 Q160 M161 W173 E176 E188
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4zrk, PDBe:4zrk, PDBj:4zrk
PDBsum4zrk
PubMed26045165
UniProtP46662|MERL_MOUSE Merlin (Gene Name=Nf2)

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