Structure of PDB 4z3c Chain C Binding Site BS02

Receptor Information

>4z3c Chain C (length=44) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKV

Ligand information

>4z3c Chain B (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gccaacgttggc

Receptor-Ligand Complex Structure

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PDB	4z3c DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Resolution	1.57 Å
Binding residue (original residue number in PDB)	K53 T73 N77 T80 H81 Q82
Binding residue (residue number reindexed from 1)	K1 T21 N25 T28 H29 Q30
Binding affinity	PDBbind-CN: Kd=2.4uM

Enzymatic activity

Enzyme Commision number

1.14.11.80: methylcytosine dioxygenase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0008270	zinc ion binding

View graph for
Molecular Function

External links

PDB	RCSB:4z3c, PDBe:4z3c, PDBj:4z3c
PDBsum	4z3c
PubMed	29276034
UniProt	O43151\|TET3_HUMAN Methylcytosine dioxygenase TET3 (Gene Name=TET3)

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