Structure of PDB 4xdl Chain C Binding Site BS02
Receptor Information
>4xdl Chain C (length=234) Species:
9606
(Homo sapiens) [
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KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITT
IGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSQTKI
RVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGD
FVAREWYKPLVWFWILVGLAYFAAVLSMIGDWLR
Ligand information
Ligand ID
K
InChI
InChI=1S/K/q+1
InChIKey
NPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0
[K+]
Formula
K
Name
POTASSIUM ION
ChEMBL
CHEMBL1233793
DrugBank
DB01345
ZINC
PDB chain
4xdl Chain C Residue 602 [
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Receptor-Ligand Complex Structure
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PDB
4xdl
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Resolution
3.5 Å
Binding residue
(original residue number in PDB)
T172 I173 G174 T281 V282 G283
Binding residue
(residue number reindexed from 1)
T100 I101 G102 T195 V196 G197
Annotation score
5
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005267
potassium channel activity
Biological Process
GO:0071805
potassium ion transmembrane transport
Cellular Component
GO:0016020
membrane
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Molecular Function
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Cellular Component
External links
PDB
RCSB:4xdl
,
PDBe:4xdl
,
PDBj:4xdl
PDBsum
4xdl
PubMed
25766236
UniProt
P57789
|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)
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