Structure of PDB 4v30 Chain C Binding Site BS02

Receptor Information
>4v30 Chain C (length=100) Species: 431944 (Magnetospirillum gryphiswaldense MSR-1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GASIFRCRQCGQTISRRDWLLEHVVFNPAGMIFRVWCFSLAQGLRLIGAP
SGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPA
Ligand information
Ligand IDLVY
InChIInChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)/t10-/m0/s1
InChIKeyGOTYRUGSSMKFNF-JTQLQIEISA-N
SMILES
SoftwareSMILES
CACTVS 3.385Nc1cccc2C(=O)N(Cc12)[C@H]3CCC(=O)NC3=O
OpenEye OEToolkits 1.9.2c1cc2c(c(c1)N)CN(C2=O)C3CCC(=O)NC3=O
OpenEye OEToolkits 1.9.2c1cc2c(c(c1)N)CN(C2=O)[C@H]3CCC(=O)NC3=O
ACDLabs 12.01O=C1NC(=O)CCC1N3C(=O)c2cccc(c2C3)N
CACTVS 3.385Nc1cccc2C(=O)N(Cc12)[CH]3CCC(=O)NC3=O
FormulaC13 H13 N3 O3
NameS-Lenalidomide
ChEMBL
DrugBank
ZINCZINC000001997127
PDB chain4v30 Chain C Residue 151 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v30 Thalidomide Mimics Uridine Binding to an Aromatic Cage in Cereblon.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		N50 F77 W79 W85 W99 Y101
Binding residue
(residue number reindexed from 1)		N27 F54 W56 W62 W76 Y78
Annotation score1
Binding affinityBindingDB: Ki=3100nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4v30, PDBe:4v30, PDBj:4v30
PDBsum4v30
PubMed25448889
UniProtA4TVL0

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