Structure of PDB 4qpl Chain C Binding Site BS02

Receptor Information
>4qpl Chain C (length=153) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPE
DFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFS
KGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAG
LRL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4qpl Chain C Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4qpl Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		C36 C39 C56 C59
Binding residue
(residue number reindexed from 1)		C7 C10 C27 C30
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
GO:0072572 poly-ADP-D-ribose binding
Biological Process
GO:0016055 Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4qpl, PDBe:4qpl, PDBj:4qpl
PDBsum4qpl
PubMed25327252
UniProtQ9CZW6|RN146_MOUSE E3 ubiquitin-protein ligase RNF146 (Gene Name=Rnf146)

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