Structure of PDB 4msj Chain C Binding Site BS02

Receptor Information
>4msj Chain C (length=187) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFKIHAYTEGGKPLRTIYLPKLLKKVFLDVVKPNTKKNLETCGILCGKLR
QNAFFITHLVIPLQEATSDTCGTTDEASLFEFQDKHNLLTLGWIHTHPTQ
TCFMSSVDLHTHCSYQLMLPEAIAIVMAPSKNTSGIFRLLDPEGLQTIVK
CRKPGLFHPHEGKVYTMVAQPGHVREINSKLQVVDLR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4msj Chain C Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4msj Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		H356 C397 H404 H406
Binding residue
(residue number reindexed from 1)		H110 C151 H158 H160
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0061578 K63-linked deubiquitinase activity
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination
GO:0070536 protein K63-linked deubiquitination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4msj, PDBe:4msj, PDBj:4msj
PDBsum4msj
PubMed24787148
UniProtQ9P371|SST2_SCHPO AMSH-like protease sst2 (Gene Name=sst2)

[Back to BioLiP]