Structure of PDB 4m26 Chain C Binding Site BS02

Receptor Information
>4m26 Chain C (length=332) Species: 58340 (Streptomyces lavendulae subsp. lavendulae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPSYSLTPAEASAVAELTLELAAAYGSFGDPVLLRDLPRLAARLPEGVQD
FLREFKLADRHGHTVIRGHDFDQRRIGPTPDHWRGRVRPGPEFPEELLLM
LYSALLGEPFGWATQQDGHLVHDIFPIRSHENDQLGMGSKQLLTWHTEDA
FHPYRSDYLILGALRNPDHVPTTVGELDLSSLSAEDIDVLFEPRYHIAPD
ESHLPKNNTIEAARFATIQRMIDERPLGPLLYGSRLDPYMRLDPYFTSVP
QDDTDARRAYDALFKVVDSGMREVVADQGDVLFIDNHRAVHGRLPFQARY
DGTDRWLKRVCVTSDLRRSREMRATSATRLLG
Ligand information
Ligand IDZZU
InChIInChI=1S/C6H14N4O3/c7-4(5(12)13)3(11)1-2-10-6(8)9/h3-4,11H,1-2,7H2,(H,12,13)(H4,8,9,10)/t3-,4-/m0/s1
InChIKeyVIDUVSPOWYVZIC-IMJSIDKUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.6.1C(CNC(=N)N)C(C(C(=O)O)N)O
ACDLabs 10.04O=C(O)C(N)C(O)CCNC(=[N@H])N
CACTVS 3.352N[CH]([CH](O)CCNC(N)=N)C(O)=O
CACTVS 3.352N[C@@H]([C@@H](O)CCNC(N)=N)C(O)=O
OpenEye OEToolkits 1.6.1C(CNC(=N)N)[C@@H]([C@@H](C(=O)O)N)O
FormulaC6 H14 N4 O3
Name(2S,3S)-3-HYDROXYARGININE
ChEMBL
DrugBank
ZINCZINC000013352215
PDB chain4m26 Chain C Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4m26 Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms.
Resolution2.02 Å
Binding residue
(original residue number in PDB)
L143 G144 H154 E156 D208 S210 D255 F258 R321
Binding residue
(residue number reindexed from 1)
L135 G136 H146 E148 D200 S202 D243 F246 R309
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.41: L-arginine hydroxylase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0102525 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity

View graph for
Molecular Function
External links
PDB RCSB:4m26, PDBe:4m26, PDBj:4m26
PDBsum4m26
PubMed24505011
UniProtG9MBV2

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