Structure of PDB 4l5r Chain C Binding Site BS02

Receptor Information
>4l5r Chain C (length=198) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPKKNISKGAVLHEKPMTVMVLTATEPFNYKEGKENMFHATVATESKYYR
VKVFNMDLKEKFTENQFITISKYFNSSGILEINETATVSEAAPNQMFEVP
KNIIRSAKETLKISKIKELDSGTLIYGVFAVEKKKVNDKSITFKIKDNED
NIKVVWDKEQHNINYEKGDKLQLFSFHLRKGNGKPILHSGNHSFIKGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4l5r Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation.
Resolution1.873 Å
Binding residue
(original residue number in PDB)		K48 K53 K180 N182 D183 K184 S185 T187 K198
Binding residue
(residue number reindexed from 1)		K3 K8 K135 N137 D138 K139 S140 T142 K153
Binding affinityPDBbind-CN: Kd=1.7uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0035458 cellular response to interferon-beta

View graph for
Biological Process
External links
PDB RCSB:4l5r, PDBe:4l5r, PDBj:4l5r
PDBsum4l5r
PubMed23850291
UniProtQ9R002|IFI2_MOUSE Interferon-activable protein 202 (Gene Name=Ifi202)

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