Structure of PDB 4juo Chain C Binding Site BS02

Receptor Information

>4juo Chain C (length=546) Species: 170187 (Streptococcus pneumoniae TIGR4)

AVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSDRIDVTINKDGSLTV
QDHTVEVIFTILHAGGKFLHGVGSSVVNALSSWLEVEITRDGAVYKQRFE
NGGKPVTTLKKIGTAPKSKTGTKVTFMPDATIFSTTDFKYNTISERLNES
AFLLKNVTLSLTDKRTDEAIEFHYEVQDFVSYLNEDKEILTPVLYFEGED
NGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYA
RKTGLLKEKEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVV
DGIVADKLTFFLMENGELASNLIRKAIKARDAREAARKARLTPAQSKNPA
KNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEE
INTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRY
MRPLVEAGHVYIAPPLYKAYAWTDGELEELRKLQRYKGLGEMNADQLWET
TMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFT

Ligand information

>4juo Chain G (length=7)

cgtgcat

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4juo Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.
• Resolution: 6.53 Å
• Binding residue (original residue number in PDB): G457 K458
• Binding residue (residue number reindexed from 1): G382 K383

Enzymatic activity

• Enzyme Commision number: 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003916 DNA topoisomerase activity
• GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006265 DNA topological change
• GO:0007059 chromosome segregation

Cellular Component

• GO:0005694 chromosome

External links

• PDB: RCSB:4juo, PDBe:4juo, PDBj:4juo
• PDBsum: 4juo
• PubMed: 23965305
• UniProt: Q59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)