Structure of PDB 4gec Chain C Binding Site BS02

Receptor Information

>4gec Chain C (length=259) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GLVPRGSMILHAQAKHGKPGLPWLVFLHGFSGDCHEWQEVGEAFADYSRL
YVDLPGHGGSAAISVDGFDDVTDLLRKTLVSYNILDFWLVGYSLGGRVAM
MAACQGLAGLCGVIVEGGHPGLQNAEQRAEAQRSDRQWVQRFLTEPLTAV
FADWYQQPVFASLNDDQRRELVALRSNNNGATLAAMLEATSLAVQPDLRA
NLSARTFAFYYLCGERDSKFRALAAELAADCHVIPRAGHNAHRENPAGVI
ASLAQILRF

Ligand information

Ligand ID

InChI

InChI=1S/ClH/h1H/p-1

InChIKey

VEXZGXHMUGYJMC-UHFFFAOYSA-M

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Cl-]

Formula

Name

CHLORIDE ION

PDB chain

4gec Chain C Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4gec Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	Y85 Y148
Binding residue (residue number reindexed from 1)	Y92 Y155
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.2.99.20: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.

Gene Ontology

	Molecular Function
GO:0016829	lyase activity
GO:0070205	2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity

	Biological Process
GO:0009234	menaquinone biosynthetic process

	Cellular Component
GO:0005829	cytosol

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4gec, PDBe:4gec, PDBj:4gec
PDBsum	4gec
PubMed	23637813
UniProt	P37355\|MENH_ECOLI 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (Gene Name=menH)

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