Structure of PDB 4eoy Chain C Binding Site BS02

Receptor Information

>4eoy Chain C (length=123) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MPSLKDEVSFENRVAETHKIRSKYPNRIPVVIERANRSNLPIIEKKKFLV
PMNMLVGEFKFILHQHINQSAYGSNMKLFRERTIYLFVNNIVPKTGLLMQ
DLYEMYKDEDGYLYMEYSSESSL

Ligand information

InChI=1S/Mg/q+2

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Mg

Name

MAGNESIUM ION

PDB chain

4eoy Chain C Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	4eoy Structural characterization and inhibition of the Plasmodium Atg8-Atg3 interaction.
Resolution	2.22 Å
Binding residue (original residue number in PDB)	R35 L41 P42 I43 Y118
Binding residue (residue number reindexed from 1)	R34 L40 P41 I42 Y117
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0008429	phosphatidylethanolamine binding
GO:0046872	metal ion binding

	Biological Process
GO:0000045	autophagosome assembly
GO:0000422	autophagy of mitochondrion
GO:0006914	autophagy
GO:0006995	cellular response to nitrogen starvation
GO:0097352	autophagosome maturation

	Cellular Component
GO:0000421	autophagosome membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0020011	apicoplast
GO:0031410	cytoplasmic vesicle

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4eoy, PDBe:4eoy, PDBj:4eoy
PDBsum	4eoy
PubMed	22982544
UniProt	Q8IJK2

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