Structure of PDB 4cyi Chain C Binding Site BS02

Receptor Information

>4cyi Chain C (length=397) Species: 209285 (Thermochaetoides thermophila)

TYDFFMPQNLREDLQKKQFATLQVIPNSGLPQLEHWHSLVPLDTSNRKNT
SCFGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNA
SIVTIHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPPPAVPENTIWG
YICQIANALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGM
NSRSVVELQQEDFVKFGKLILSLATGTLPAHLNNIPAALETLGNKYSANL
KSAVNWLLDTSSGETKTIEHFMTGIASQMTTFFDLALQDNDEKLFHLARE
VENGRIARSLMKLLTILERGDRYQLKLFRDYVFHRVDADGKPNLSIGHML
TCMSKLEAGVDENILLTSRDNETVFVLSYRELRQMYDRAFNELVKAS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4cyi Chain C Residue 1000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4cyi Structural Basis for Pan3 Binding to Pan2 and its Function in Mrna Recruitment and Deadenylation
• Resolution: 2.42 Å
• Binding residue (original residue number in PDB): D257 S271
• Binding residue (residue number reindexed from 1): D43 S57
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
• GO:0006397 mRNA processing
• GO:0006468 protein phosphorylation

Cellular Component

• GO:0031251 PAN complex

External links

• PDB: RCSB:4cyi, PDBe:4cyi, PDBj:4cyi
• PDBsum: 4cyi
• PubMed: 24872509
• UniProt: G0S0Y3|PAN3_CHATD PAN2-PAN3 deadenylation complex subunit PAN3 (Gene Name=PAN3)