Structure of PDB 4csa Chain C Binding Site BS02

Receptor Information

>4csa Chain C (length=164) Species: 162145 (human metapneumovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SRKAPCKYEVRGKCNRGSECKFNHNYWSWPDRYLLIRSNYLLNQLLRDTD
RAAGREDRTQDFVLGSTNVVQGYIDDNQSITKAAACYSLHNIIKQLQEVE
VRQARDNKLSDSKHVALHNLVLSYMEMSKTPASLINNLKRLPREKLKKLA
KLIIDLSAGAENDS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4csa Chain C Residue 1174 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4csa Drastic Changes in Conformational Dynamics of the Antiterminator M2-1 Regulate Transcription Efficiency in Pneumovirinae.
Resolution	2.28 Å
Binding residue (original residue number in PDB)	C7 C15 C21 H25
Binding residue (residue number reindexed from 1)	C6 C14 C20 H24
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003746	translation elongation factor activity
GO:0005198	structural molecule activity
GO:0046872	metal ion binding

	Biological Process
GO:0006414	translational elongation
GO:0046782	regulation of viral transcription

	Cellular Component
GO:0005737	cytoplasm
GO:0030430	host cell cytoplasm
GO:0042025	host cell nucleus
GO:0044423	virion component

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4csa, PDBe:4csa, PDBj:4csa
PDBsum	4csa
PubMed	24842877
UniProt	Q8QN58

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