Structure of PDB 4cn2 Chain C Binding Site BS02

Receptor Information
>4cn2 Chain C (length=82) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCL
IDKRQRNRCQYCRYQKCLAMGMKREAVQEERQ
Ligand information
Receptor-Ligand Complex Structure
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PDB4cn2 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
Resolution2.069 Å
Binding residue
(original residue number in PDB)		E153 G154 R161 R184 N185 Q188 R191
Binding residue
(residue number reindexed from 1)		E25 G26 R33 R56 N57 Q60 R63
Binding affinityPDBbind-CN: Kd=38nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4cn2, PDBe:4cn2, PDBj:4cn2
PDBsum4cn2
PubMed25645674
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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