Structure of PDB 4bpw Chain C Binding Site BS02

Receptor Information
>4bpw Chain C (length=367) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDI
YIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQE
KELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFK
HRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVH
LSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHD
ELQQSFQKSHNSLQRWEHLKKVASRYPWLEWEIMLQYCFPRLDINVSKGI
NHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELTSLAPY
VKVFEHFLENLDKSRKG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4bpw Chain C Residue 1410 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4bpw Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Resolution3.003 Å
Binding residue
(original residue number in PDB)		D109 D306
Binding residue
(residue number reindexed from 1)		D106 D293
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.102: DNA primase AEP.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003896 DNA primase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032553 ribonucleotide binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0016020 membrane
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bpw, PDBe:4bpw, PDBj:4bpw
PDBsum4bpw
PubMed24043831
UniProtP49642|PRI1_HUMAN DNA primase small subunit (Gene Name=PRIM1)

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