Structure of PDB 4ad9 Chain C Binding Site BS02

Receptor Information
>4ad9 Chain C (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLQRVERLSNRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIP
EYISCLKQALTEFNTAIQEIVVTHWHRDHSGGIGDICKSINNDTTYCIKK
LPRNPQREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALL
LEEENAIFSGDCILGEGTTVFEDLYDYMNSLKELLKIKADIIYPGHGPVI
HNAEAKIQQYISHRNIREQQILTLFRENFEKSFTVMELVKIIYKNTPENL
HEMAKHNLLLHLKKLEKEGKIFSNTDPDKKWKAHL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ad9 Chain C Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ad9 Identification of Lactb2, a Metallo-Beta-Lactamase Protein, as a Human Mitochondrial Endoribonuclease
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H77 H79 H145 D164
Binding residue
(residue number reindexed from 1)		H74 H76 H142 D161
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4ad9, PDBe:4ad9, PDBj:4ad9
PDBsum4ad9
PubMed26826708
UniProtQ53H82|LACB2_HUMAN Endoribonuclease LACTB2 (Gene Name=LACTB2)

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