Structure of PDB 3ts8 Chain C Binding Site BS02

Receptor Information

>3ts8 Chain C (length=234) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFVQLAKTVPV
QLYVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERSSDSDGLAPPQH
LIRVEGNLRAEYLDDPNTFRHSVVVPYEPPEVGSDYTTIYFKFMCNSSCM
GGMNRRPILVIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKKT
MDGEYFTLQIRGRERFEQFRERNEALELKDAQAT

Ligand information

>3ts8 Chain L (length=26) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ctcaacatgttgggacatgttccttt

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3ts8 Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	K120 R248
Binding residue (residue number reindexed from 1)	K27 R155

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process
GO:0051262	protein tetramerization

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:3ts8, PDBe:3ts8, PDBj:3ts8
PDBsum	3ts8
PubMed	21933903
UniProt	P04637\|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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