Structure of PDB 3slp Chain C Binding Site BS02

Receptor Information
>3slp Chain C (length=226) Species: 10710 (Lambdavirus lambda) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTPDIILQRTGIDVRAVEQGDDAWHKLRLGVITASEVHNVIAKPRSGKKW
PDMKMSYFHTLLAEVCTGVAPEVNAKALAWGKQYENDARTLFEFTSGVNV
TESPIIYRDESMRTACSPDGLCSDGNGLELKCPFTSRDFMKFRLGGFEAI
KSAYMAQVQYSMWVTRKNAWYFANYDPRMKREGLHYVVIERDEKYMASFD
EIVPEFIEKMDEALAEIGFVFGEQWR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3slp Chain C Residue 227 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3slp Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity.
Resolution2.3 Å
Binding residue
(original residue number in PDB)
D119 E129
Binding residue
(residue number reindexed from 1)
D119 E129
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E93 E102 D109 E129 L130 K131
Catalytic site (residue number reindexed from 1) E93 E102 D109 E129 L130 K131
Enzyme Commision number 3.1.11.3: exodeoxyribonuclease (lambda-induced).
Gene Ontology
Molecular Function
GO:0004527 exonuclease activity
GO:0046872 metal ion binding
GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity
Biological Process
GO:0006259 DNA metabolic process

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Molecular Function

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Biological Process
External links
PDB RCSB:3slp, PDBe:3slp, PDBj:3slp
PDBsum3slp
PubMed21730170
UniProtP03697|EXO_LAMBD Exonuclease (Gene Name=exo)

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