Structure of PDB 3nmx Chain C Binding Site BS02

Receptor Information
>3nmx Chain C (length=323) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAHAPVEHQICPAVCVLMKLSFDEEHRH
AMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVA
NKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLR
EVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALA
FLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQT
LLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSK
HKMIAMGSAAALRNLMANRPAKY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3nmx Structural basis for the recognition of Asef by adenomatous polyposis coli.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		F458 M503 N507 F510 G511 K516 Q542 S546 R549 N550 W553 W593 N594
Binding residue
(residue number reindexed from 1)		F44 M89 N93 F96 G97 K102 Q128 S132 R135 N136 W139 W179 N180
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3nmx, PDBe:3nmx, PDBj:3nmx
PDBsum3nmx
PubMed21788986
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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