Structure of PDB 3lon Chain C Binding Site BS02

Receptor Information
>3lon Chain C (length=151) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M
Ligand information
Receptor-Ligand Complex Structure
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PDB3lon Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor
Resolution2.2 Å
Binding residue
(original residue number in PDB)		V29 G31 E32 V33 I35 V36 S37 R62 T63 I64 A65 P88 G90
Binding residue
(residue number reindexed from 1)		V1 G3 E4 V5 I7 V8 S9 R34 T35 I36 A37 P60 G62
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H29 D53 G109 S111
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3lon, PDBe:3lon, PDBj:3lon
PDBsum3lon
PubMed
UniProtQ9ELS8

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