Structure of PDB 3iwy Chain C Binding Site BS02

Receptor Information
>3iwy Chain C (length=83) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
Ligand information
Receptor-Ligand Complex Structure
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PDB3iwy D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
Resolution1.93 Å
Binding residue
(original residue number in PDB)		L54 F55 G58 Q59 I61 M62 Y67 Q72 V93 H96 Y100
Binding residue
(residue number reindexed from 1)		L29 F30 G33 Q34 I36 M37 Y42 Q47 V68 H71 Y75
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3iwy, PDBe:3iwy, PDBj:3iwy
PDBsum3iwy
PubMed20660730
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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