Structure of PDB 3iag Chain C Binding Site BS02

Receptor Information

>3iag Chain C (length=422) Species: 10090 (Mus musculus)

PPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLM
GSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAK
TLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKN
ADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLD
DDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDA
DDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGA
SWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQ
NFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPV
TLVRNDGVIYSTSLTFTYTPEP

Ligand information

>3iag Chain B (length=15)

ttatcgtgtgaaaga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3iag Thermodynamic and structural insights into CSL-DNA complexes.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): K90 R91 F92 K192 R218 S221 T223
• Binding residue (residue number reindexed from 1): K38 R39 F40 K140 R166 S169 T171
• Binding affinity: PDBbind-CN: Kd=333nM

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3iag, PDBe:3iag, PDBj:3iag
• PDBsum: 3iag
• PubMed: 19866488
• UniProt: P31266|SUH_MOUSE Recombining binding protein suppressor of hairless (Gene Name=Rbpj)