Structure of PDB 3deg Chain C Binding Site BS02

Receptor Information
>3deg Chain C (length=545) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERER
GITIKAQSVTLDYKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALL
VVDAGQGVEAQTLANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDI
VGIDATDAVRCSAKTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWF
DNYLGVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIFTPKQVDRTEL
KCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLF
PVSSDDYEAFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEI
IQERLEREYDLDLITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELR
EPIAECHMLLPQAYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEV
VLDFFDRLKSTSRGYASLDYNFKRFQASDMVRVDVLINGERVDALALITH
RDNSQNRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARSTVKQL
Ligand information
>3deg Chain I (length=29) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cugcuccuaguacgagaggaccggagugg
<<<<<<<...............>>>>>>>
Receptor-Ligand Complex Structure
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PDB3deg A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
Resolution10.9 Å
Binding residue
(original residue number in PDB)		R50 D456 K459 S460 T461 R463 G464
Binding residue
(residue number reindexed from 1)		R50 D456 K459 S460 T461 R463 G464
Enzymatic activity
Catalytic site (original residue number in PDB) K17 S18 T53 H81
Catalytic site (residue number reindexed from 1) K17 S18 T53 H81
Enzyme Commision number 3.6.5.n1: elongation factor 4.
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0043023 ribosomal large subunit binding
GO:0043024 ribosomal small subunit binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0009268 response to pH
GO:0009409 response to cold
GO:0009651 response to salt stress
GO:0042274 ribosomal small subunit biogenesis
GO:0045727 positive regulation of translation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3deg, PDBe:3deg, PDBj:3deg
PDBsum3deg
PubMed19172743
UniProtP60785|LEPA_ECOLI Elongation factor 4 (Gene Name=lepA)

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