Structure of PDB 3d23 Chain C Binding Site BS02

Receptor Information
>3d23 Chain C (length=298) Species: 443239 (Human coronavirus HKU1 (isolate N1)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIVKMVSPTSKIEPCIVSVTYGSMTLNGLWLDDKVYCPRHVICSSSNMNE
PDYSALLCRVTLGDFTIMSGRMSLTVVSYQMQGCQLVLTVSLQNPYTPKY
TFGNVKPGETFTVLAAYNGRPQGAFHVTMRSSYTIKGSFLCGSCGSVGYV
LTGDSVKFVYMHQLELSTGCHTGTDFTGNFYGPYRDAQVVQLPVKDYVQT
VNVIAWLYAAILNNCAWFVQNDVCSTEDFNVWAMANGFSQVKADLVLDAL
ASMTGVSIETLLAAIKRLYMGFQGRQILGSCTFEDELAPSDVYQQLAG
Ligand information
Receptor-Ligand Complex Structure
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PDB3d23 Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		M25 T26
Binding residue
(residue number reindexed from 1)		M24 T25
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G143 C145
Catalytic site (residue number reindexed from 1) H40 G142 C144
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:3d23, PDBe:3d23, PDBj:3d23
PDBsum3d23
PubMed18562531
UniProtP0C6U3|R1A_CVHN1 Replicase polyprotein 1a (Gene Name=1a)

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