Structure of PDB 2zp7 Chain C Binding Site BS02

Receptor Information
>2zp7 Chain C (length=391) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SWSEAFGKGAGRIQASTIRELLKLTQRPGILSFAGGLPAPELFPKEEAAE
AAARILREKGEVALQYSPTEGYAPLRAFVAEWIGVRPEEVLITTGSQQAL
DLVGKVFLDEGSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGPDLDAL
EEVLKRERPRFLYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDA
YRELYFGEARLPSLFELAREAGYPGVIYLGSFSKVLSPGLRVAFAVAHPE
ALQKLVQAKQGADLHTPMLNQMLVHELLKEGFSERLERVRRVYREKAQAM
LHALDREVPKEVRYTRPKGGMFVWMELPKGLSAEGLFRRALEENVAFVPG
GPFFANGGGENTLRLSYATLDREGIAEGVRRLGRALKGLLA
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain2zp7 Chain C Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2zp7 Mechanism for multiple-substrates recognition of alpha-aminoadipate aminotransferase from Thermus thermophilus
Resolution2.26 Å
Binding residue
(original residue number in PDB)		G99 S100 Q101 Y125 N174 D202 A204 Y205 S235 S237 K238 R245
Binding residue
(residue number reindexed from 1)		G95 S96 Q97 Y121 N170 D198 A200 Y201 S231 S233 K234 R241
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.39: 2-aminoadipate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0009058 biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:1901605 alpha-amino acid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2zp7, PDBe:2zp7, PDBj:2zp7
PDBsum2zp7
PubMed18831049
UniProtQ72LL6|LYSN_THET2 2-aminoadipate transaminase (Gene Name=lysN)

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