Structure of PDB 2wdr Chain C Binding Site BS02

Receptor Information

>2wdr Chain C (length=122) Species: 562 (Escherichia coli)

QRPVNLDLQTIRFPITAIASILHRVSGVITFVAVGILLWLLGTSLSSPEG
FEQASAIMGSFFVKFIMWGILTALAYHVVVGIRHMMMDFGYLEETFEAGK
RSAKISFVITVVLSLLAGVLVW

Ligand information

• Ligand ID: PCI
• InChI: InChI=1S/C6HCl5O/c7-1-2(8)4(10)6(12)5(11)3(1)9/h12H
• InChIKey: IZUPBVBPLAPZRR-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: c1(c(c(c(c(c1Cl)Cl)Cl)Cl)Cl)O
  ACDLabs 10.04: Clc1c(O)c(Cl)c(Cl)c(Cl)c1Cl
  CACTVS 3.341: Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl
• Formula: C6 H Cl5 O
• Name: PENTACHLOROPHENOL
• ChEMBL: CHEMBL75967
• ZINC: ZINC000001529471
• PDB chain: 2wdr Chain C Residue 1131

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2wdr Structure of Escherichia Coli Succinate:Quinone Oxidoreductase with an Occupied and Empty Quinone- Binding Site.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): F20 I28 R31
• Binding residue (residue number reindexed from 1): F13 I21 R24
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.3.5.1: succinate dehydrogenase.

Gene Ontology

Molecular Function

• GO:0008177 succinate dehydrogenase (quinone) activity
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:0048039 ubiquinone binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0009060 aerobic respiration
• GO:0017004 cytochrome complex assembly
• GO:0019646 aerobic electron transport chain

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:2wdr, PDBe:2wdr, PDBj:2wdr
• PDBsum: 2wdr
• PubMed: 19710024
• UniProt: P69054|DHSC_ECOLI Succinate dehydrogenase cytochrome b556 subunit (Gene Name=sdhC)