Structure of PDB 2p5o Chain C Binding Site BS02

Receptor Information
>2p5o Chain C (length=853) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNV
GKLKYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYY
AKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPI
PNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERP
SDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNMLFRA
QRTEVAGMTAQINRKLLINSLYGALGNVWFRYYDLRNATAITTFGQMALQ
WIERKVNEYLNEVCGTEGEAFVLYGDTDSIYVSADKIIDKVGESKFRDTN
HWVDFLDKFARERMEPAIDRGFREMCEYMNNKQHLMFMDREAIAGPPLGS
KGIGGFWTGKKRYALNVWDMEGTRYAEPKLKIMGLETQKSSTPKAVQKAL
KECIRRMLQEGEESLQEYFKEFEKEFRQLNYISIASVSSANNIAKYDVGG
FPGPKCPFHIRGILTYNRAIKGNIDAPQVVEGEKVYVLPLREGNPFGDKC
IAWPSGTEITDLIKDDVLHWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKA
SLF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2p5o Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		N284 D623 M728 G729 Q733 K734 S735 S783 S784 N786 Y791 P802 H804
Binding residue
(residue number reindexed from 1)		N284 D578 M683 G684 Q688 K689 S690 S738 S739 N741 Y746 P757 H759
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2p5o, PDBe:2p5o, PDBj:2p5o
PDBsum2p5o
PubMed15057283
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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