Structure of PDB 2p5g Chain C Binding Site BS02

Receptor Information
>2p5g Chain C (length=885) Species: 12353 (Escherichia phage RB69) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF
DIYGKPCTRKLFANMRDASQWIKRMEDIGLEALGMDDFKLAYLSDTYNYE
IKYDHTKIRVANFDIEVTSPDGFPEPSQAKHPIDAITHYDSIDDRFYVFD
LLNSPYGNVEEWSIEIAAKLQEQGGDEVPSEIIDKIIYMPFDNEKELLME
YLNFWQQKTPVILTGWNVESFAIPYVYNRIKNIFGESTAKRLSPHRKTRV
KVIENMYGSREIITLFGISVLDYIDLYKKFSFTNQPSYSLDYISEFELNV
GKLKYDGPISKLRESNHQRYISYNIIAVYRVLQIDAKRQFINLSLDMGYY
AKIQIQSVFSPIKTWDAIIFNSLKEQNKVIPQGRSHPVQPYPGAFVKEPI
PNRYKYVMSFDLTSLYPSIIRQVNISPETIAGTFKVAPLHDYINAVAERP
SDVYSCSPNGMMYYKDRDGVVPTEITKVFNQRKEHKGYMLAAQRNGEIIK
EALDVDYRFDDEIKEKIKKLSAKSLNEMLFRAQRTEVAGMTAQINRKLLI
NSLYGALGNVWFRYYDLRNATAITTFGQMALQWIERKVNEYLNEVCGTEG
EAFVLYGDTDSIYVSADKIIDKVGESKFRDTNHWVDFLDKFARERMEPAI
DRGFREMCEYMNNKQHLMFMDREAIAGPPLGSKGIGGFWTGKKRYALNVW
DMEGTRYAEPKLKIMGLETQKSSTPKAVQKALKECIRRMLQEGEESLQEY
FKEFEKEFRQLNYISIASVSSANNIAKYDVGGFPGPKCPFHIRGILTYNR
AIKGNIDAPQVVEGEKVYVLPLREGNPFGDKCIAWPSGTEITDLIKDDVL
HWMDYTVLLEKTFIKPLEGFTSAAKLDYEKKASLF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2p5g Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		N284 Y416 T622 D623 K706 M728 G729 K734 S735 S736 S783 S784 N786 K790 Y791 H804
Binding residue
(residue number reindexed from 1)		N284 Y416 T609 D610 K693 M715 G716 K721 S722 S723 S770 S771 N773 K777 Y778 H791
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2p5g, PDBe:2p5g, PDBj:2p5g
PDBsum2p5g
PubMed17718515
UniProtQ38087|DPOL_BPR69 DNA-directed DNA polymerase (Gene Name=43)

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