Structure of PDB 2mlf Chain C Binding Site BS02

Receptor Information
>2mlf Chain C (length=72) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGKSEEELSDLFRMFDKNADGYIDLDELKIMLQATGETITEDDIEELMKD
GDKNNDGRIDYDEFLEFMKDVE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2mlf Chain C Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2mlf The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I.
ResolutionN/A
Binding residue
(original residue number in PDB)		D105 D109 Y111 I112 E116
Binding residue
(residue number reindexed from 1)		D16 D20 Y22 I23 E27
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:2mlf, PDBe:2mlf, PDBj:2mlf
PDBsum2mlf
PubMed18803402
UniProtP63316|TNNC1_HUMAN Troponin C, slow skeletal and cardiac muscles (Gene Name=TNNC1)

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