Structure of PDB 2hvw Chain C Binding Site BS02

Receptor Information
>2hvw Chain C (length=146) Species: 1309 (Streptococcus mutans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLSWQDYFMANAELISKRSTCNRAYVGAVLVKNNRIIATGYNGGVADTDN
CDDVGHEMEDGHCIRTVHAEMNALIQCAKEGISANNTEIYVTHFPCINCT
KALLQAGVKKITYNTAYRIHPFAIELMTQKEVEYVQHDVPRVKLGE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2hvw Chain C Residue 1005 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2hvw Crystal structures of Streptococcus mutans 2'-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP x Mg2+.
Resolution1.67 Å
Binding residue
(original residue number in PDB)		C24 C54 H59 C66
Binding residue
(residue number reindexed from 1)		C21 C51 H56 C63
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.12: dCMP deaminase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2hvw, PDBe:2hvw, PDBj:2hvw
PDBsum2hvw
PubMed18255096
UniProtQ8DSE5

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