Structure of PDB 2gvf Chain C Binding Site BS02

Receptor Information
>2gvf Chain C (length=152) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTN
VDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLL
SPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLET
TM
Ligand information
>2gvf Chain D (length=16) Species: 11104 (Hepatitis C virus (isolate 1)) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB2gvf P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Q28 V29 G31 E32 V33 I35 V36 S37 R62 T63 I64 A65 W85 P88 G90 A111
Binding residue
(residue number reindexed from 1)		Q1 V2 G4 E5 V6 I8 V9 S10 R35 T36 I37 A38 W58 P61 G63 A84
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H30 D54 G110 S112
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:2gvf, PDBe:2gvf, PDBj:2gvf
PDBsum2gvf
PubMed16730985
UniProtP26664|POLG_HCV1 Genome polyprotein

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