Structure of PDB 2f9u Chain C Binding Site BS02

Receptor Information
>2f9u Chain C (length=152) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTN
VDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLL
SPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLET
TM
Ligand information
Receptor-Ligand Complex Structure
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PDB2f9u Novel Inhibitors of Hepatitis C NS3-NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q28 V29 G31 E32 V33 I35 V36 S37 T63 I64 A65 P88 G90 A111
Binding residue
(residue number reindexed from 1)		Q1 V2 G4 E5 V6 I8 V9 S10 T36 I37 A38 P61 G63 A84
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H30 D54 G110 S112
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019062 virion attachment to host cell
GO:0019087 transformation of host cell by virus
GO:0046718 symbiont entry into host cell
GO:0097264 self proteolysis
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2f9u, PDBe:2f9u, PDBj:2f9u
PDBsum2f9u
PubMed16413182
UniProtQ91RS4

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