Structure of PDB 2a4r Chain C Binding Site BS02

Receptor Information
>2a4r Chain C (length=151) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M
Ligand information
>2a4r Chain D (length=16) Species: 63746 (Hepatitis C virus (isolate H77)) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB2a4r Hepatitis C Virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency.
Resolution2.4 Å
Binding residue
(original residue number in PDB)
V29 G31 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 P88 G90
Binding residue
(residue number reindexed from 1)
V1 G3 E4 V5 Q6 I7 V8 S9 R34 T35 I36 A37 P60 G62
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H29 D53 G109 S111
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function

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Biological Process
External links
PDB RCSB:2a4r, PDBe:2a4r, PDBj:2a4r
PDBsum2a4r
PubMed16112862
UniProtP27958|POLG_HCV77 Genome polyprotein

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