Structure of PDB 2a4g Chain C Binding Site BS02

Receptor Information
>2a4g Chain C (length=151) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M
Ligand information
>2a4g Chain D (length=16) Species: 31647 (Hepatitis C virus subtype 1b) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB2a4g Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		V29 G31 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 W85 G90
Binding residue
(residue number reindexed from 1)		V1 G3 E4 V5 Q6 I7 V8 S9 R34 T35 I36 A37 W57 G62
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H29 D53 G109 S111
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:2a4g, PDBe:2a4g, PDBj:2a4g
PDBsum2a4g
PubMed16087332
UniProtP26664|POLG_HCV1 Genome polyprotein

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