Structure of PDB 1yo5 Chain C Binding Site BS02

Receptor Information

>1yo5 Chain C (length=88) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKN
RPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHP

Ligand information

>1yo5 Chain B (length=13) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

acacatcctgcta

Receptor-Ligand Complex Structure

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PDB	1yo5 Analysis of the 2.0 A Crystal Structure of the Protein-DNA Complex of the Human PDEF Ets Domain Bound to the Prostate Specific Antigen Regulatory Site
Resolution	2.0 Å
Binding residue (original residue number in PDB)	H250 L251 W291 K295 M300 K304 R307 S308 Y312
Binding residue (residue number reindexed from 1)	H4 L5 W45 K49 M54 K58 R61 S62 Y66

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II

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Molecular Function

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Biological Process

External links

PDB	RCSB:1yo5, PDBe:1yo5, PDBj:1yo5
PDBsum	1yo5
PubMed	15882048
UniProt	O95238\|SPDEF_HUMAN SAM pointed domain-containing Ets transcription factor (Gene Name=SPDEF)

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