Structure of PDB 1wup Chain C Binding Site BS02
Receptor Information
>1wup Chain C (length=217) Species:
615
(Serratia marcescens) [
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SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFT
AKDTEKLVTWFVERGYKIKGSISSHFHSESTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERK
ILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGD
ASLLKLTLEQAVKGLNE
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
1wup Chain C Residue 306 [
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Receptor-Ligand Complex Structure
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PDB
1wup
Probing the role of Asp-120(81) of metallo-beta-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography.
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
E81 C158 H197
Binding residue
(residue number reindexed from 1)
E79 C156 H195
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H77 H79 E81 H139 C158 K161 N167 H197
Catalytic site (residue number reindexed from 1)
H75 H77 E79 H137 C156 K159 N165 H195
Enzyme Commision number
3.5.2.6
: beta-lactamase.
Gene Ontology
Molecular Function
GO:0008270
zinc ion binding
GO:0008800
beta-lactamase activity
GO:0016787
hydrolase activity
GO:0046872
metal ion binding
Biological Process
GO:0017001
antibiotic catabolic process
GO:0046677
response to antibiotic
Cellular Component
GO:0042597
periplasmic space
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1wup
,
PDBe:1wup
,
PDBj:1wup
PDBsum
1wup
PubMed
15788415
UniProt
P52699
|BLAB_SERMA Metallo-beta-lactamase type 2
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