Structure of PDB 1u7p Chain C Binding Site BS02

Receptor Information
>1u7p Chain C (length=163) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTVRDRRGQNIQLYPEV
PEVLGRLQSLGVPVAAASRTSEIQGANQLLELFDLGKYFIQREIYPGSKV
THFERLHHKTGVPFSQMVFFDDENRNIIDVGRLGVTCIHIRDGMSLQTLT
QGLETFAKAQAGL
Ligand information
Ligand IDWO4
InChIInChI=1S/4O.W/q;;2*-1;
InChIKeyPBYZMCDFOULPGH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-][W](=O)(=O)[O-]
ACDLabs 10.04
CACTVS 3.341		[O-][W]([O-])(=O)=O
FormulaO4 W
NameTUNGSTATE(VI)ION
ChEMBL
DrugBank
ZINC
PDB chain1u7p Chain C Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1u7p X-ray Crystal Structure of the Hypothetical Phosphotyrosine Phosphatase MDP-1 of the Haloacid Dehalogenase Superfamily
Resolution1.9 Å
Binding residue
(original residue number in PDB)		D11 L12 D13 S69 R70 K100
Binding residue
(residue number reindexed from 1)		D10 L11 D12 S68 R69 K99
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.-
3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1u7p, PDBe:1u7p, PDBj:1u7p
PDBsum1u7p
PubMed15461449
UniProtQ9D967|MGDP1_MOUSE Magnesium-dependent phosphatase 1 (Gene Name=Mdp1)

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