Structure of PDB 1s9k Chain C Binding Site BS02

Receptor Information

>1s9k Chain C (length=280) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGY
MENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKV
LEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRV
HIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMIL
TGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNK
HIRTPVKVNFYVINGKRKRSQPQHFTYHPV

Ligand information

>1s9k Chain B (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aactattacacatattttca

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1s9k Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site
Resolution	3.1 Å
Binding residue (original residue number in PDB)	Y424 T426 E427 K520 R522 N523 K538 R572 R665
Binding residue (residue number reindexed from 1)	Y26 T28 E29 K122 R124 N125 K140 R174 R267

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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External links

PDB	RCSB:1s9k, PDBe:1s9k, PDBj:1s9k
PDBsum	1s9k
PubMed
UniProt	Q13469\|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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