Structure of PDB 1rr8 Chain C Binding Site BS02

Receptor Information
>1rr8 Chain C (length=494) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLS
PKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERI
ANFKIEPPGLSRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHK
WKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRL
KKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETAD
TVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKN
LQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQQAPREENKQIALGTSKL
NYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1rr8 Mechanisms of camptothecin resistance by human topoisomerase I mutations
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R362 G363 R364 H367 R488 A489 N491 K493 T501 K532 D533 T585 A586 K587
Binding residue
(residue number reindexed from 1)		R162 G163 R164 H167 R288 A289 N291 K293 T301 K332 D333 T385 A386 K387
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rr8, PDBe:1rr8, PDBj:1rr8
PDBsum1rr8
PubMed15165849
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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