Structure of PDB 1q1s Chain C Binding Site BS02

Receptor Information
>1q1s Chain C (length=434) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MADIGSNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPID
NIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA
IPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL
AVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHN
DPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPA
LRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT
AGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQI
VYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIM
IEECGGLDKIEALQRHENESVYKASLNLIEKYFS
Ligand information
>1q1s Chain B (length=15) Species: 1891767 (Betapolyomavirus macacae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DAQHAAPPKKKRKVE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1q1s Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha
Resolution2.3 Å
Binding residue
(original residue number in PDB)		M64 A65 S105 R106 P110 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273 Y277 L307 P308
Binding residue
(residue number reindexed from 1)		M1 A2 S42 R43 P47 W79 N83 S86 G87 T92 Q118 W121 N125 G128 D129 W168 R175 W210 Y214 L244 P245
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1q1s, PDBe:1q1s, PDBj:1q1s
PDBsum1q1s
PubMed12852786
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

[Back to BioLiP]