Structure of PDB 1g5b Chain C Binding Site BS02

Receptor Information

>1g5b Chain C (length=221) Species: 10710 (Lambdavirus lambda)

MRYYEKIDGSKYRNIWVVGDLHGCYTNLMNKLDTIGFDNKKDLLISVGDL
VDRGAENVECLELITFPWFRAVRGNHEQMMIDGLSERGNVNHWLLNGGGW
FFNLDYDKEILAKALAHKADELPLIIELVSKDKKYVICHADYPFDEYEFG
KPVDHQQVIWNRERISNSQNGIVKEIKGADTFIFGHTPAVKPLKFANQMY
IDTGAVFCGNLTLIQVQGAGA

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 1g5b Chain C Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1g5b Structure of the bacteriophage lambda Ser/Thr protein phosphatase with sulfate ion bound in two coordination modes.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): D49 N75 H139 H186
• Binding residue (residue number reindexed from 1): D49 N75 H139 H186
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Gene Ontology

Molecular Function

• GO:0004721 phosphoprotein phosphatase activity
• GO:0004722 protein serine/threonine phosphatase activity
• GO:0005515 protein binding
• GO:0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0017018 myosin phosphatase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0110154 RNA decapping

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1g5b, PDBe:1g5b, PDBj:1g5b
• PDBsum: 1g5b
• PubMed: 11112522
• UniProt: P03772|PP_LAMBD Serine/threonine-protein phosphatase