Structure of PDB 8ova Chain Bw Binding Site BS02

Receptor Information

>8ova Chain Bw (length=230) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IKRAAFKQQQTENFKKAIAANKVAAAALKKLAYSRGLKYSREYRSTEKKL
AGLRRNARQHGNYYLEAKPKVAVVTRIRGIAKVPPKQRKILQLLRLRQIF
NTVFVRLNKPMENMLRAVEPYIAYGYPSLSTVRAMVYKRGHLKINGQRVK
ITDNQMIKDKYHNDDIVCAEDIVNQIYACGKHFRTVTNGLWPFKLAPPAG
GMRQKRRHFVEGGDYGNRDTLINRFLARMI

Ligand information

>8ova Chain BD (length=119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggguacgaccauacuuggccgaaugcaccauaucccguccgauuugugaa
guuaagcggccacaggccucguuaguacggcgaucagugauggcgcugga
acccgggguguuguacucu

<<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>..
...>>>>>>>>>>>>>>>.

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution	2.47 Å
Binding residue (original residue number in PDB)	E146 R233 R234 H235 E238
Binding residue (residue number reindexed from 1)	E119 R206 R207 H208 E211

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit

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External links

PDB	RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum	8ova
PubMed	37985661
UniProt	Q57V35

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