Structure of PDB 8ove Chain Bl Binding Site BS02

Receptor Information
>8ove Chain Bl (length=144) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFSGSVAANRSKKIHQLTKKTTRVKRDRKSPRLYMKGTLAGYTRGLHGQN
KNTALVRIENVNTTEDAKWYVGKRVCYVYHGYKIKRCVRWSKAPARRSNT
RAIWGRITRPHGTSGTVRVKFNGSSVPASAIGRRIRVYLYPSRI
Ligand information
>8ove Chain BB (length=1109) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caacugcagaccguacucaucaccgcaucagguccccaagcaucgaaugc
ucugguacauagagaaagguacacucagggaagucggcaaaauagaugcg
uaaguucgcaagaagcauuggcucugagggcaauugccaacucagaacug
cuuacggcggggaauccaacuguauaauuaaaacauagguuugugaugca
uccaagugguguaugucgcaaacugauuucugcccagugcucugaauguc
aacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuauga
cucucuuaagguagccaaaugccucgucuuccaauuagagacgcgcauga
auggauuaaugagauucccucugucccgaguuacuaucuagcgaaacgac
agucaagggaacggacuugaagggcuaagcggggaaagaagacccuguug
aguuugacuccagucuggcucugugcggcgacuuacguugcuucacuuau
cgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccg
ucuaggcugacgcgugcggaacucugcgccaacgggguggaauucuccgg
agucuuguuucgagacaucugccagauggggaguuuggcuggggcggcau
aucuguuacacgacaacgcagguguccuaaggcgagcucagugggaucuc
acguggaacacaagcguaaaugcuugcuugauuaacgauuuccaguacga
aucgagacugcgaaagcaaggccagcgauccuuugcgaagaacaggaaau
augaacaaaucauaccagaggugucagaauaauuaccacagggauaacug
gcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgau
gucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggauugu
ucacccacugacagggaacgugagcuggguuuagaccgucgugagacagg
uugguuuuacccuacuuggcuggagauugcgaguaaaagauuauccgcgc
aaagcggaggcaguccguuuuuuucugggucugccguuggguggcaugug
cuuggcgcu
......................<<......>>......<<<<<...>>>>
>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.
....<..>......>>>>><<.<<<<<<<<<<<>>>>>..>>>>>>.>>.
.........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<
<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.
...<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<.......>>>>>.....>..
...>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>..........
..<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<
<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>...<
<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>>>.
....<..<...>..>...................<<<.<<..>>.>>>..
.>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..
<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>
>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>
>>>..>>.<<<....>>>.>>.........<<<<<..............<
<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<
<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>......
.<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.....
....>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>
>>....>>..>>>.>>>>>>>.......................<<<<..
...>>>>...<<<...........>>>..........<..<.<.......
>.>.>....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		F7 S8 G9 A13 N14 S16 K17 K18 H20 Q21
Binding residue
(residue number reindexed from 1)		F2 S3 G4 A8 N9 S11 K12 K13 H15 Q16
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ584G9

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