Structure of PDB 8ove Chain Bk Binding Site BS02

Receptor Information

>8ove Chain Bk (length=123) Species: 5702 (Trypanosoma brucei brucei)

IVKIRDLKEKGKDDLLKQLSEFKKELSQLRVSQQMNVGAARLGRIRTIRK
GIARIMTVLNKNERENLRKFYSDKKLRSAKPKTLRAKLTHRRRLALKANE
KNRKTRRQLRMAHKFPRRIYAVK

Ligand information

>8ove Chain BC (length=160)

aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagc
aaagugcgauaagugguaucaauugcagaaucauugcccaaucuuugaac
gcaaacggcgcaugggagaagcucgagccauccccgugcaugccacauuu
cucagugucg

.........................................<<<<<<<<<
....>>>>.....(<<<<......>>........>>>>.)...>>>....
<<.....>><<<<<<<....<<<..>>>....>>>>>>>...........
..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): A42 R52 A56 R57 M59 T60 N63 R67 K85 K90 T92 H93 R94 R96
• Binding residue (residue number reindexed from 1): A39 R49 A53 R54 M56 T57 N60 R64 K82 K87 T89 H90 R91 R93

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ove, PDBe:8ove, PDBj:8ove
• PDBsum: 8ove
• PubMed: 37985661
• UniProt: Q38FW8