Structure of PDB 8ova Chain Bk Binding Site BS02

Receptor Information

>8ova Chain Bk (length=123) Species: 5702 (Trypanosoma brucei brucei)

IVKIRDLKEKGKDDLLKQLSEFKKELSQLRVSQQMNVGAARLGRIRTIRK
GIARIMTVLNKNERENLRKFYSDKKLRSAKPKTLRAKLTHRRRLALKANE
KNRKTRRQLRMAHKFPRRIYAVK

Ligand information

>8ova Chain BC (length=160)

aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagc
aaagugcgauaagugguaucaauugcagaaauugcccaaucuuugaacgc
aaacggcgcaugggagaagcucgagccauccccgugcaugccacauuucu
cagugucgaa

.........................................<<<<<<<<<
....>>>>.....(<<<<......>>......>>>>.)...>>>....<<
.....>><<<<<<<....<<<..>>>....>>>>>>>.............
..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
• Resolution: 2.47 Å
• Binding residue (original residue number in PDB): I7 K53 R57 M59 N63 R67 K85 K90 T92 H93 R94 R96
• Binding residue (residue number reindexed from 1): I4 K50 R54 M56 N60 R64 K82 K87 T89 H90 R91 R93

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ova, PDBe:8ova, PDBj:8ova
• PDBsum: 8ova
• PubMed: 37985661
• UniProt: Q38FW8